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Products Details
Product Description
– ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer’s disease[1].
Web ID
– HY-144316
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C30H32FN5O2
References
– [1]Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer’s disease. Eur J Med Chem. 2022;229:114095.
CAS Number
– 2765251-12-3
Molecular Weight
– 513.61
SMILES
– O=C(C1=CC2=C(C3=CC=NC(NC(C4CC4)=O)=C3N2)C=C1)NCCC5CCN(CC5)CC6=C(C=CC=C6)F
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE);GSK-3
Isoform
– AChE;BChE;GSK-3β
Pathway
– Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
