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Products Details
Product Description
– ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the Pin1 (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC50 of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells[1].
Web ID
– HY-143903
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H23ClN2O3S
References
– [1]Liu L, et al. Computational and Structure-Based Development of High Potent Cell-Active Covalent Inhibitor Targeting the Peptidyl-Prolyl Isomerase NIMA-Interacting-1 (Pin1). J Med Chem. 2022;65(3):2174-2190.
CAS Number
– 2883498-73-3
Molecular Weight
– 454.97
SMILES
– O=C(CSC12CCN(CC2)C(CCl)=O)N1CC3=CC=C(O3)C4=CC=CC5=C4C=CC=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Others
Pathway
– Others
Product type
– Reference compound
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