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Product Description
– Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone hydrochloride has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1].
Web ID
– HY-14542A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H22Cl2N4OS
References
– [1]Rollema H, et al. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000;48(3):229-237.|[2]Schmidt AW, et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001;425(3):197-201.|[3]Seeger TF, et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995;275(1):101-113.|[4]Park S, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012;61(6):787-793.
CAS Number
– 122883-93-6
Molecular Weight
– 449.40
SMILES
– ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.Cl
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Dopamine Receptor
Isoform
– 5-HT1 Receptor;5-HT2 Receptor;D2 Receptor
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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