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ZIP acetate(863987-12-6 free base)
Price range: 128 CAD through 1,808 CAD
Products Details
Product Description
– ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 – 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Web ID
– TP1924L1
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C92H158N30O19
References
– Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID:
Molecular Weight
– C92H158N30O19
Compound Purity
– 0.9468
SMILES
– CCCCCCCCCCCCCC(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O.CC(=O)O
Pathway
– Cytoskeletal Signaling|||Chromatin/Epigenetic
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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