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Products Details
Product Description
– Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].
Web ID
– HY-120234
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H41N3O5
References
– [1]Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46. |[2]Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57.
CAS Number
– 133407-83-7
Molecular Weight
– 475.62
SMILES
– O=C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)N[C@@H](CC(C)C)C(N[C@H](C=O)CCCC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Proteasome;γ-secretase
Pathway
– Apoptosis;Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt
Product type
– Peptides
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
