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Products Details
Product Description
– Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM). Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].
Web ID
– HY-138096
Shipping
– Room temperature
Molecular Formula
– C29H39N3O5
References
– [1]Orlowski M, et al. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16;32(6):1563-72.|[2]Ding L, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005 Sep;37(9):1881-9.
CAS Number
– 133429-58-0
Molecular Weight
– 509.64
SMILES
– O=C(N[C@H](C=O)CC1=CC=CC=C1)[C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Proteasome
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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