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(Z)-Guggulsterone
Price range: 146 CAD through 939 CAD
Products Details
Product Description
– (Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
Web ID
– T17280
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C21H28O2
Citations
– 1. Wu Y, Zhou T, Qian D, et al.Z-Guggulsterone Induces Cell Cycle Arrest and Apoptosis by Targeting the p53/CCNB1/PLK1 Pathway in Triple-Negative Breast Cancer.ACS Omega.2023
2. Sun H, Su X, Liu Y, et al.Roseburia intestinalis relieves intrahepatic cholestasis of pregnancy through bile acid/FXR-FGF15 in rats.iScience.2023: 108392.
3. Dou X, Huo T, Liu Y, et al.Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation.European Journal of Medicinal Chemistry.2024: 116323.
References
– Xiao D, et al. z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther. 2008 Jan;7(1):171-80.
CAS Number
– 39025-23-5
Molecular Weight
– C21H28O2
Compound Purity
– 0.9847
SMILES
– CC=C1/C(=O)C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Target
– PARP
Pathway
– Angiogenesis|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors|||Apoptosis|||PI3K/Akt/mTOR signaling
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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