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YKL-05-099
Price range: 109 CAD through 1,102 CAD
Products Details
Product Description
– YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. It can inhibit the activity of SIK1 (IC50: 10 nM) and SIK3 (IC50: 30 nM), and has a slightly weaker inhibitory effect on SIK2 (IC50: 40 nM). [1]
Web ID
– T17271
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C32H34ClN7O3
Citations
– 1. Wan J, He Z, Zhao Y, et al.Novel strategy of senescence elimination via toxicity-exempted kinome perturbations by nanoliposome-based thermosensitive hydrogel for osteoarthritis therapy.Advanced Composites and Hybrid Materials.2023, 6(3): 104.
References
– Sundberg TB, et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 Aug 19;11(8):2105-11.
CAS Number
– 1936529-65-5
Molecular Weight
– C32H34ClN7O3
Compound Purity
– 0.9989
SMILES
– COc1ccc(nc1)N1C(=O)N(Cc2cnc(Nc3ccc(cc3OC)C3CCN(C)CC3)nc12)c1c(C)cccc1Cl
Target
– Autophagy|||Apoptosis|||Ferroptosis|||ERK|||Nrf2
Pathway
– PI3K/Akt/mTOR signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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