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Yangonin
$80 – $264
Products Details
Product Description
– Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC50 and a Ki of 1.79 μM and 0.72 μM, respectively.
Web ID
– HY-N0919
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C15H14O4
References
– [1]Ligresti A, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB<sub>1</sub> receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9.|[2]Ma J, et al. Yangonin blocks tumor necrosis factor-α-induced nuclear factor-κB-dependent transcription by inhibiting the transactivation potential of the RelA/p65 subunit. J Pharmacol Sci. 2012;118(4):447-54.|[3]Wruck CJ, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95.
CAS Number
– 500-62-9
Molecular Weight
– 258.27
Compound Purity
– 99.79
SMILES
– O=C1C=C(OC)C=C(/C=C/C2=CC=C(OC)C=C2)O1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 25 mg/mL (ultrasonic)
Target
– Autophagy;Cannabinoid Receptor;NF-κB
Isoform
– CB1;RelA/p65
Pathway
– Autophagy;GPCR/G Protein;Neuronal Signaling;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
