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Wogonin
$60 – $360
Products Details
Product Description
– Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects.
Web ID
– HY-N0400
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H12O5
References
– [1]He L, et al. Wogonin induced G1 cell cycle arrest by regulating Wnt/β-catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells. Toxicology. 2013 Oct 4;312:36-47.|[2]Yang L, et al. Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells. Biochem Cell Biol. 2009 Dec;87(6):933-42.|[3]Li HD, et al. Wogonin attenuates inflammation by activating PPAR-γ in alcoholic liver disease. Int Immunopharmacol. 2017 Sep;50:95-106.
CAS Number
– 632-85-9
Molecular Weight
– 284.26
Compound Purity
– 99.98
SMILES
– O=C1C=C(C2=CC=CC=C2)OC3=C(OC)C(O)=CC(O)=C13
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;CDK;Wnt
Isoform
– CDK8
Pathway
– Apoptosis;Autophagy;Cell Cycle/DNA Damage;Stem Cell/Wnt
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
