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Products Details
Product Description
– Wf-516 hydrochloride is an inhibitor of 5-HT reuptake, and an antagonist of 5-HT1A and 5-HT2A receptors, with Ki of 5 nM and 40 nM for 5-HT1A receptor and 5-HT2A receptor in humans, respectively.Wf-516 hydrochloride has potent antidepressant activity.
Web ID
– HY-19417
Shipping
– Room temperature
Molecular Formula
– C25H26Cl3N3O4
References
– [1]El Mansari M, et al. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jan;376(5):351-61. Epub 2007 Nov 30.|[2]Saijo T, et al. Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain. PLoS One. 2012;7(8):e42589.
CAS Number
– 310392-93-9
Molecular Weight
– 538.85
SMILES
– O[C@H](COC1=C2C=C(C3=NN=C(C)O3)OC2=CC=C1)CN(CC4)CCC4C5=CC=C(Cl)C(Cl)=C5.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Serotonin Transporter
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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