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Products Details
Product Description
– WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslink</b agent with an adduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences[1].
Web ID
– HY-147740
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H30N6O4
References
– [1]Pumuye PP, et al. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks with unique structural features. Bioorg Med Chem. 2020 Feb 1;28(3):115260.
CAS Number
– 70492-21-6
Molecular Weight
– 442.51
SMILES
– NCCNCCNC1=CC=C(C2=C1C(C3=C(C=CC(O)=C3C2=O)O)=O)NCCNCCN
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– DNA Alkylator/Crosslinker
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
