Vorinostat
Add to CompareAdded to Compare

Download Files:

Vorinostat

SKU T1583-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 70 CAD through 162 CAD

Products Details

Product Description

– Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

Web ID

– T1583

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C14H20N2O3

Citations

– 1. Wellinger L C, Hogg S J, Newman D M, et al. BET Inhibition Enhances TNF Mediated Anti-Tumor Immunity. Cancer Immunology Research. 2022, 10(1): 87-107. 2. Du T, Hu X, Hou Z, et al.Re-expression of epigenetically silenced PTPRR by histone acetylation sensitizes RAS-mutant lung adenocarcinoma to SHP2 inhibition.Cellular and Molecular Life Sciences.2024, 81(1): 1-14. 3. Yuting Meng,Xixi Qian,Li Zhao,Nan Li,Shengjie Wu,Baoan Chen,Tong Sun,Xuerong Wang Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma. Cancer Cell International. 2021, 21(1): 1-12. 4. Wang C, Huang M, Lin Y, et al.ENO2-derived phosphoenolpyruvate functions as an endogenous inhibitor of HDAC1 and confers resistance to antiangiogenic therapy.Nature Metabolism.2023: 1-22. 5. Liang X L, Ouyang L, Yu N N, et al.Histone deacetylase inhibitor pracinostat suppresses colorectal cancer by inducing CDK5-Drp1 signaling-mediated peripheral mitofission.Journal of Pharmaceutical Analysis.2023 6. Wang L, Wu J, Sramek M, et al.Heterogeneous enhancer states orchestrate β cell responses to metabolic stress.Nature Communications.2024, 15(1): 9361. 7. Bian R, Shang Y, Xu N, et al.HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism.Cellular Signalling.2025: 111583. 8. In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

References

– Bernhart E, et al. Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines. Oncotarget. 2017 Aug 24;8(44):77254-77267.

CAS Number

– 149647-78-9

Molecular Weight

– C14H20N2O3

Compound Purity

– 0.9993

SMILES

– N(C(CCCCCCC(NO)=O)=O)C1=CC=CC=C1

Target

– Endogenous Metabolite

Pathway

– Chromatin/Epigenetic|||Apoptosis|||Microbiology/Virology|||Autophagy|||DNA Damage/DNA Repair

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Aspirin
Aspirin Price range: 50 CAD through 139 CAD
1 g1 mL * 10 mM (in DMSO)5 g

1000 in stock

Add to cart
4-(Imidazol-1-yl)phenol
4-(Imidazol-1-yl)phenol 46 CAD

1000 in stock

Select options
AChE-IN-23
AChE-IN-23 Price range: 66 CAD through 150 CAD
100 mg200 mg50 mg

1000 in stock

Select options
Jedi2
Jedi2 Price range: 53 CAD through 1,117 CAD
1 mg1 mL * 10 mM (in DMSO)5 mg

1000 in stock

Select options
4-Hydroxy-6-methylcoumarin
4-Hydroxy-6-methylcoumarin Price range: 46 CAD through 78 CAD
1 mL * 10 mM (in DMSO)500 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });