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VH-298
Price range: 62 CAD through 995 CAD
Products Details
Product Description
– VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein-protein interaction downstream of HIF-α hydroxylation by PHD enzymes.
Web ID
– TQ0121
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C27H33N5O4S
Citations
– 1. Wang J, Wen Y, Zhang Y, et al.An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies.Journal of Advanced Research.2023
References
– Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312.
CAS Number
– 2097381-85-4
Molecular Weight
– C27H33N5O4S
Compound Purity
– 1
SMILES
– Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)C2(CC2)C#N)C(C)(C)C)cc1
Pathway
– Angiogenesis|||PROTAC|||Chromatin/Epigenetic
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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