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Verteporfin
$96 – $960
Products Details
Product Description
– Verteporfin (CL 318952) is a photosensitizer for photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with conditions such as age-related macular degeneration. Verteporfin is a YAP inhibitor which disrupts YAP-TEAD interactions. Verteporfin induces cell apoptosis[1]. Verteporfinis an autophagy inhibitor that blocks autophagy at an early stage by inhibiting autophagosome formation[3].
Web ID
– HY-B0146
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C41H42N4O8
References
– [1]Donohue E, et al. The autophagy inhibitor verteporfin moderately enhances the antitumor activity of gemcitabine in a pancreatic ductal adenocarcinoma model.J Cancer. 2013 Aug 28;4(7):585-96.|[2]Pan W, et al. Verteporfin can Reverse the NSC 125973 Resistance Induced by YAP Over-Expression in HCT-8/T Cells without Photoactivation through Inhibiting YAP Expression. Cell Physiol Biochem. 2016;39(2):481-90.|[3]Morishita T, et al. The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with BMS-354825. Oncotarget. 2016 Aug 2.
CAS Number
– 129497-78-5
Molecular Weight
– 718.79
Compound Purity
– 99.58
SMILES
– C[C@]1(/C2=C/C(N3)=C4C)C(C(/C=C(C(C)=C/5C=C)NC5=C/C6=N/C(C(CCC(OC)=O)=C6C)=CC3=C4CCC(O)=O)=N2)=CC=C(C(OC)=O)[C@H]1C(OC)=O.C[C@]7(/C8=C/C(N9)=C%10C)C(C(/C=C(C(C)=C/%11C=C)NC%11=C/C%12=N/C(C(CCC(O)=O)=C%12C)=CC9=C%10CCC(OC)=O)=N8)=CC=C(C(OC)=O)[C@H]7C(OC)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMF : 10 mg/mL (ultrasonic;warming;heat to 60°C)|DMSO : 50 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;YAP
Pathway
– Apoptosis;Autophagy;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
