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VER-246608
Price range: 77 CAD through 1,230 CAD
Products Details
Product Description
– VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
Web ID
– T17224
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C28H23ClF2N4O4
CAS Number
– 1684386-71-7
Molecular Weight
– C28H23ClF2N4O4
Compound Purity
– 0.985
SMILES
– Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O
Target
– Autophagy|||NMDAR
Pathway
– PI3K/Akt/mTOR signaling|||Metabolism
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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