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Valproic acid
$50 – $80
Products Details
Product Description
– Valproic acid (VPA) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches[1][2][3][4][5][6][7].
Web ID
– HY-10585
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C8H16O2
Citations
– Biochem Biophys Res Commun. 2022.|Biochim Biophys Acta Gene Regul Mech. 2020 Sep;1863(9):194597.|Biomaterials. 2018 Dec 6;193:30-46.|bioRxiv. 2023 Apr 21.|Biotechnol Bioeng. 2021 Sep 3.|Brain Science Advances. 2022 Feb.|Cell Death Differ. 2023 Jun 15.|EMBO J. 2021 Apr 28;e106771.|J Biol Chem. 2023 Jan 31;102971.|J Ethnopharmacol. 2023 Feb 17;116258.|Lett Drug Des Discover. 2019 Nov.|Life Sci. 2023 Jul 8;121921.|Mil Med Res. 2020 Nov 1;7(1):52.|Mil Med Res. 2020 Sep 6;7(1):42. |Oncogene. 2021 Apr;40(15):2711-2724.|Phytomedicine. 19 August 2022, 154403.|Research Square Preprint. 2022 Jan.|Research Square Preprint. 2022 Jul.|Sci Adv. 2021 Aug 11;7(33):eabf4416.|Sci Rep. 2020 Sep 16;10(1):15201.|Sci Total Environ. 2021, 147014.|Sci Total Environ. 2023 Aug 23;903:166505.|STAR Protoc. 16 September 2022, 101638.|Acta Pharmacol Sin. 2020 Jun 17. |BMC Cancer. 2022 Aug 8;22(1):864.|Clin Dev Immunol. 2020 Aug 4;2020:4384696.|Ecotoxicol Environ Saf. 2022 Jun 14;241:113752.|J Genet Genomics. 2023 Sep 11;S1673-8527(23)00184-4.|J Interferon Cytokine Res. 2021 Dec;41(12):439-449.|Toxicol Lett. 2021 Apr 24;346:47-56.
References
– [1]Routy JP, et al. Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study. HIV Med. 2012 May;13(5):291-6.|[2]Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7.|[3]Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41.|[4]Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10.|[5]Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005.|[6]Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28.|[7]Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50.
CAS Number
– 99-66-1
Molecular Weight
– 144.21
Compound Purity
– 98.67
SMILES
– CCCC(CCC)C(O)=O
Clinical Information
– Launched
Research Area
– Cancer; Infection; Metabolic Disease; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming)
Target
– Apoptosis;Autophagy;Endogenous Metabolite;HDAC;HIV;Mitophagy;Notch
Isoform
– HDAC;HDAC1;HDAC2
Pathway
– Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
