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Vadimezan
$96 – $840
Products Details
Product Description
– Vadimezan (DMXAA; ASA-404), the tumor vascular disrupting agent (tumor-VDA), is a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. Vadimezan has anti-influenza virus H1N1-PR8 activities.
Web ID
– HY-10964
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C17H14O4
References
– [1]Downey CM, et al. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2’3′-cGAMP, induces M2 macrophage repolarization. PLoS One. 2014 Jun 18;9(6):e99988.|[2]Shirey KA, et al. The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivo. J Leukoc Biol. 2011 Mar;89(3):351-7.
CAS Number
– 117570-53-3
Molecular Weight
– 282.29
Compound Purity
– 99.80
SMILES
– O=C(O)CC1=CC=CC(C2=O)=C1OC3=C2C=CC(C)=C3C
Clinical Information
– Phase 3
Research Area
– Cancer; Infection
Solubility
– 7.5% sodium bicarbonate : 6.67 mg/mL (ultrasonic)|DMSO : 7.14 mg/mL (ultrasonic)
Target
– IFNAR;Influenza Virus;STING
Pathway
– Anti-infection;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
