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Urolithin A
$50 – $410
Products Details
Product Description
– Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis[1][2].
Web ID
– HY-100599
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H8O4
References
– [1]Wang Y, et al. In vitro antiproliferative and antioxidant effects of urolithin A, the colonic metabolite of ellagic acid, on hepatocellular carcinomas HepG2 cells. Toxicol In Vitro. 2015 Aug;29(5):1107-15.|[2]Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.|[3]Gong Z, et al. Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice.|[4]Zhao W, et al. Metabolite of ellagitannins, urolithin A induces autophagy and inhibits metastasis in human sw620colorectal cancer cells. Mol Carcinog. 2018 Feb;57(2):193-200.|[5]Qiu Z, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013 Sep;59:428-37.|[6]González-SarrÃas A, et al. Antiproliferative activity of the ellagic acid-derived gut microbiota isourolithin A and comparison with its urolithin A isomer: the role of cell metabolism.Eur J Nutr. 2017 Mar;56(2):831-841.
CAS Number
– 1143-70-0
Molecular Weight
– 228.20
Compound Purity
– 98.05
SMILES
– O=C1C2=CC(O)=CC=C2C3=CC=C(O)C=C3O1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 30 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;DNA/RNA Synthesis;Drug Metabolite;Endogenous Metabolite;Reactive Oxygen Species
Isoform
– Microbial Metabolite
Pathway
– Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
