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Upadacitinib
Price range: 62 CAD through 1,059 CAD
Products Details
Product Description
– Upadacitinib (ABT-494) (ABT-494) is a selective Janus kinase (JAK) 1 inhibitor, which is being studied for the treatment of several autoimmune disorders in the IC50 of 43 nM.
Web ID
– T7503
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C17H19F3N6O
Citations
– 1. Si H, Wang J, He R, et al. Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor. Frontiers in oncology. 2021, 11: 807200-807200.
2. Wang F, Wang S, Zhang C, et al.Noncanonical JAK1/STAT3 interactions with TGF-β modulate myofibroblast transdifferentiation and fibrosis.American Journal of Physiology-Lung Cellular and Molecular Physiology.2022, 323(6): L698-L714.
References
– Nakayamada S, et al. Recent Progress in JAK Inhibitors for the Treatment of Rheumatoid Arthritis. BioDrugs. 2016 Oct;30(5):407-419.
CAS Number
– 1310726-60-3
Molecular Weight
– C17H19F3N6O
Compound Purity
– 0.9994
SMILES
– CC[C@@H]1CN(C[C@@H]1c1cnc2cnc3[nH]ccc3n12)C(=O)NCC(F)(F)F
Pathway
– Angiogenesis|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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