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UNC2250
$77 – $814
Products Details
Product Description
– UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
Web ID
– HY-15797
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H36N6O2
References
– [1]Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56(23): p. 9683-92.|[2]Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.
CAS Number
– 1493694-70-4
Molecular Weight
– 440.58
Compound Purity
– 99.22
SMILES
– CCCCNC1=NC(N[C@@H]2CC[C@@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 0.1 M HCL : 12.5 mg/mL (ultrasonic;adjust pH to 3 with HCl)|DMSO : ≥ 10 mg/mL
Target
– TAM Receptor
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
