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UNC0638
$79 – $581
Products Details
Product Description
– UNC0638 selectively inhibits G9a and GLP histone methyltransferase activity with IC50s of less than 15 nM and 19 nM, respectively. UNC0638 has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities.
Web ID
– HY-15273
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H47N5O2
References
– [1]Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5.|[2]Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74.|[3]Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47.
CAS Number
– 1255580-76-7
Molecular Weight
– 509.73
Compound Purity
– 99.71
SMILES
– CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(C5CCCCC5)=N2)CC1)C
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 1M HCl : 100 mg/mL (ultrasonic;adjust pH to 1 with HCl)|DMSO : ≥ 30 mg/mL
Target
– Autophagy;Histone Methyltransferase;Influenza Virus;VSV
Isoform
– EHMT1/GLP/KMT1D;EHMT2/G9a/KMT1C
Pathway
– Anti-infection;Autophagy;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
