Products Details

Product Description

– UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis[1][2].

Web ID

– HY-117359

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C15H16ClN7O3.xHCl

References

– [1]Pasupuleti N, et, al. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15.|[2]Leon LJ, et, al. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038.

CAS Number

– 1115177-19-9

Molecular Weight

– N/A

SMILES

– O=C(CNC1=C(Cl)N=C(C(NC(N)=N)=O)C(N)=N1)OCC2=CC=CC=C2.Cl.[x]

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Apoptosis;PAI-1

Pathway

– Apoptosis;Metabolic Enzyme/Protease

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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