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Products Details
Product Description
– UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis[1][2].
Web ID
– HY-117359
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C15H16ClN7O3.xHCl
References
– [1]Pasupuleti N, et, al. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15.|[2]Leon LJ, et, al. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038.
CAS Number
– 1115177-19-9
Molecular Weight
– N/A
SMILES
– O=C(CNC1=C(Cl)N=C(C(NC(N)=N)=O)C(N)=N1)OCC2=CC=CC=C2.Cl.[x]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;PAI-1
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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