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Tubulysin A
$560 – $2,530
Products Details
Product Description
– Tubulysin A (TubA) is an antibiotic and highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) isolated from myxobacteria. Tubulysins are a family of cytotoxic peptides consisting of 9 members (A-I). Tubulysin A has anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative activities. Tubulysin A is also an inducer of apoptosis (apoptosis), arresting cells in the G2/M phase, effectively inhibiting tubulin polymerization, and inducing depolymerization of detached microtubules. Tubulysin A is potent cytostatic against multiple tumor cell lines with IC50 in the pmol range. Tubulysin A acts as an ADC cytotoxin (ADC Cytotoxin) to synthesize ADC[1][2][3].
Web ID
– HY-15995
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C43H65N5O10S
References
– [1]Kaur G, et al. Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product. Biochem J. 2006 Jun 1;396(2):235-42.|[2]Sasse F, et al. Tubulysins, new cytostatic peptides from myxobacteria acting on microtubuli. Production, isolation, physico-chemical and biological properties. J Antibiot (Tokyo). 2000 Sep;53(9):879-85.|[3]Khalil MW, et al. Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria. Chembiochem. 2006 Apr;7(4):678-83.
CAS Number
– 205304-86-5
Molecular Weight
– 844.07
Compound Purity
– 99.08
SMILES
– O=C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC1)N1C)=O)N(COC(CC(C)C)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(O)=O)CC3=CC=C(O)C=C3)=O)=CS2)OC(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– ADC Cytotoxin;Antibiotic;Microtubule/Tubulin
Isoform
– Traditional Cytotoxic Agents
Pathway
– Antibody-drug Conjugate/ADC Related;Anti-infection;Cell Cycle/DNA Damage;Cytoskeleton
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
