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Tubulin/PARP-IN-1
SKU
HY-157165-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics, Microtubule/Tubulin;PARP
Products Details
Product Description
– Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].
Web ID
– HY-157165
Shipping
– Room temperature
Molecular Formula
– C19H13FO3
References
– [1]Sharma S et al. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2276665.
Molecular Weight
– 308.30
SMILES
– O=C1C=C(OC2=C1C=CC(C3=COC=C3)=C2)C4C=CC(F)=CC4
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin;PARP
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.