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Products Details
Product Description
– Tubulin/PARP-IN-1 (compound 14) is a dual PARP-tubulin inhibitor with activity against endometrial cancer. Tubulin/PARP-IN-1 inhibits PARP and tubulin with IC50s of 74 nM (PARP1), 109 nM (PARP2), and 1.4 μM (Microtubule/Tubulin), respectively. Tubulin/PARP-IN-1 can induce apoptosis and autophagy and cause cell cycle arrest in the G2/M phase[1].
Web ID
– HY-157165
Shipping
– Room temperature
Molecular Formula
– C19H13FO3
References
– [1]Sharma S et al. Flavone-based dual PARP-Tubulin inhibitor manifesting efficacy against endometrial cancer. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2276665.
Molecular Weight
– 308.30
SMILES
– O=C1C=C(OC2=C1C=CC(C3=COC=C3)=C2)C4C=CC(F)=CC4
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin;PARP
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics
Product type
– Reference compound
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