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Tubulin/MMP-IN-1
SKU
HY-146006-Get quote
Category Reference compound
Tags Cancer, Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease, Microtubule/Tubulin;MMP
Products Details
Product Description
– Tubulin/MMP-IN-1 (compound 15g) is a potent inhibitor of tubulin and MMP. Tubulin/MMP-IN-1 has the potential for the research of cancer diseases. Tubulin/MMP-IN-1 suppresses tubulin polymerization, induces cell cycle arrest at the G2/M phase, leads to reactive oxidative stress (ROS) generation of HepG2 cells, and results in apoptosis by the mitochondrial-dependent apoptotic pathway[1].
Web ID
– HY-146006
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C38H44NO9P
References
– [1]Yang L, et al. Dual-functional antitumor conjugates improving the anti-metastasis effect of combretastatin A4 by targeting tubulin polymerization and matrix metalloproteinases [published online ahead of print, 2022 May 5]. Eur J Med Chem. 2022;238:114439.
Molecular Weight
– 689.73
SMILES
– CCOP(OCC)(C(C1=CC=CC=C1C)NC2=CC=C(C=C2)CC(OC3=CC(/C=CC4=CC(OC)=C(C(OC)=C4)OC)=CC=C3OC)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin;MMP
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.