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Triptolide
Price range: 59 CAD through 933 CAD
Products Details
Product Description
– Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.
Web ID
– T2179
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H24O6
Citations
– 1. Zhang G M, Huang S S, Ye L X, et al. Reciprocal positive regulation between BRD4 and YAP in GNAQ-mutant uveal melanoma cells confers sensitivity to BET inhibitors. Pharmacological Research. 2022: 106464.
2. Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.
3. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.
4. Wang Y, Jing Y, Huang D, et al.Triptolide ameliorates renal tubulointerstitial fibrosis through EZH2.bioRxiv.2023: 2023.01. 29.526092.
5. Wu Y, Tang K, Wang C, et al.Establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features.Acta Pharmaceutica Sinica B.2025
References
– Yan X, et al. Triptolide inhibits cell proliferation and tumorigenicity of human neuroblastoma cells. Mol Med Rep. 2015 Feb;11(2):791-6.
CAS Number
– 38748-32-2
Molecular Weight
– C20H24O6
Compound Purity
– 0.9997
SMILES
– [H][C@@]12C[C@@H]3O[C@@]33[C@H](O)[C@]4(O[C@H]4[C@@H]4O[C@]34[C@@]1(C)CCC1=C2COC1=O)C(C)C
Pathway
– Apoptosis|||Cytoskeletal Signaling|||Metabolism|||NF-κB
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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