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Tripterin
Price range: 74 CAD through 274 CAD
Products Details
Product Description
– Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodulatory properties.
Web ID
– T3028
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H38O4
Citations
– 1. Qing T, Yan L, Wang S, et al.Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway.Ecotoxicology and Environmental Safety.2023, 252: 114623.
2. Zhang H, Cai J, Li C, et al.Wogonin inhibits latent HIV-1 reactivation by downregulating histone crotonylation.Phytomedicine.2023: 154855.
3. Zhao W, Xu C, Peng L, et al.cAMP/PKA signaling promotes AKT deactivation by reducing CIP2A expression, thereby facilitating decidualization.Molecular and Cellular Endocrinology.2023: 111946.
4. Li S, Hao L, Hu X, et al.A systematic study on the treatment of hepatitis B-related hepatocellular carcinoma with drugs based on bioinformatics and key target reverse network pharmacology and experimental verification.Infectious Agents and Cancer.2023, 18(1): 41.
5. Liu X, Hu Q, Wang W, et al. A protein-fragment complementation assay reveals that celastrol and gambogic acid suppress ERα mutants in breast cancer. Biochemical Pharmacology. 2021, 188: 114583.
6. Jiang X, Chen S, Zhang Q, et al. Celastrol is a novel selective agonist of cannabinoid receptor 2 with anti-inflammatory and anti-fibrotic activity in a mouse model of systemic sclerosis. Phytomedicine. 2019: 153160
7. Liu Q, Yue Y, Wang S, et al. Celastrol Attenuates the Remodeling of Pulmonary Vascular and Right Ventricular in Monocrotaline-Induced Pulmonary Arterial Hypertension in Rats. Cardiovascular Diagnosis and Therapy. 2022 Feb;12(1):88-102. doi: 10.21037/cdt-21-360.
8. Tan W, Cheng S, Qiu Q, et al.Celastrol exerts antiarrhythmic effects in chronic heart failure via NLRP3/Caspase-1/IL-1β signaling pathway.Biomedicine & Pharmacotherapy.2024, 177: 117121.
9. Li H, Liu Q, Liu C, et al.Identification of SNHG11 as a Therapeutic Target in Pulmonary Hypertension.American Journal of Respiratory Cell and Molecular Biology.2024 (ja).
References
– Yang H, et al. Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine,” is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Res. 2006 May 1;66(9):4758-65.
CAS Number
– 34157-83-0
Molecular Weight
– C29H38O4
Compound Purity
– 0.9948
SMILES
– CC1=C(O)C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(O)=O
Pathway
– Autophagy|||Ubiquitination|||Apoptosis|||Proteases/Proteasome
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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