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Product Description
– Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer’s disease[1][2][3].
Web ID
– HY-N10408
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C20H25ClO6
References
– [1]Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179(1):28-37.|[2]Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40(4):1066-70.|[3]Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer’s Disease. J Neurochem. 2015 Apr;133(1):38-52.
CAS Number
– 132368-08-2
Molecular Weight
– 396.86
SMILES
– C[C@@]([C@@]1([H])C2)(CCC3=C1COC3=O)[C@]4([C@@]([C@H]5Cl)([H])O4)[C@]6([C@@H]([C@@](O)5C(C)C)O)[C@@]2([H])O6
Clinical Information
– No Development Reported
Research Area
– Cancer; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy
Pathway
– Apoptosis;Autophagy
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
