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Trimethadione
$60 – $66
Products Details
Product Description
– Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) is an oxazolidinedione anticonvulsant agent widely used against absences seizures. Trimethadione also is a T-type calcium channel blocker which has antihyperalgesic effects[1][2].
Web ID
– HY-A0092
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Molecular Formula
– C6H9NO3
References
– [1]Pastore V, et, al. Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides. Bioorg Med Chem. 2013 Feb 15;21(4):841-6.|[2]Barton ME, et, al. The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil. Eur J Pharmacol. 2005 Oct 3;521(1-3):79-85.
CAS Number
– 127-48-0
Molecular Weight
– 143.14
Compound Purity
– 98.0
SMILES
– O=C(N1C)OC(C)(C)C1=O
Clinical Information
– Launched
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 40 mg/mL
Target
– Calcium Channel
Isoform
– T-type calcium channel
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
