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Trimebutine (maleate)
$50 – $90
Products Details
Product Description
– Trimebutine maleate is an orally anti-tumor agent. Trimebutine maleate selectively suppresses stemness and proliferation of ovarian cancer stem cells (CSCs). Trimebutine maleate reduces the colonic muscle hypercontractility, modulates gastrointestinal motility, induces apoptosis and can be used for the research of glioma/glioblastoma and irritable bowel syndrome[1][2][3][4][5][6].
Web ID
– HY-B0380A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C26H33NO9
References
– [1]Long Y, et al. Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome [J]. European Journal of Pharmacology, 2010, 636(1-3): 159-165.|[2]Lee H, et al. Repositioning trimebutine maleate as a cancer treatment targeting ovarian cancer stem cells [J]. Cells, 2021, 10(4): 918.|[3]Fan Y, et al. Trimebutine promotes glioma cell apoptosis as a potential anti-tumor agent [J]. Frontiers in Pharmacology, 2018, 9: 664.|[4]Cenac N, et al. A novel orally administered trimebutine compound (GIC‐1001) is anti‐nociceptive and features peripheral opioid agonistic activity and hydrogen sulphide‐releasing capacity in mice [J]. European journal of pain, 2016, 20(5): 723-730.|[5]Long Y, et al. Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome [J]. European Journal of Pharmacology, 2010, 636(1-3): 159-165.|[6]Lee H T, Kim B J. Trimebutine as a modulator of gastrointestinal motility [J]. Archives of pharmacal research, 2011, 34(6): 861-864.
CAS Number
– 34140-59-5
Molecular Weight
– 503.54
Compound Purity
– 99.79
SMILES
– O=C(O)/C=CC(O)=O.O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 25 mg/mL (ultrasonic)
Target
– Akt;Apoptosis;ERK;Oct3/4
Pathway
– Apoptosis;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
