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Triamterene
$66 – $119
Products Details
Product Description
– Triamterene blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner, which used as a mild diuretic. Triamterene is an inhibitor of the TGR5 receptor[1][2].
Web ID
– HY-B0575
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C12H11N7
References
– [1]Busch, A.E., et al., Blockade of epithelial Na+ channels by triamterenes – underlying mechanisms and molecular basis. Pflugers Arch, 1996. 432(5): p. 760-6.|[2]Gilfrich, H.J., et al., Pharmacokinetics of triamterene after i.v. administration to man: determination of bioavailability. Eur J Clin Pharmacol, 1983. 25(2): p. 237-41.|[3]Shafaroodi H, et al. A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice. Epilepsy Res. 2016 Mar;121:8-13.|[4]Devane J, et al. The effects of amiloride and triamterene on urinary magnesium excretion in conscious saline-loaded rats. Br J Pharmacol. 1981 Feb;72(2):285-9.|[5]Moghadam NH, et al. In vitro cytotoxicity and DNA/HSA interaction study of triamterene using molecular modelling and multi-spectroscopic methods. J Biomol Struct Dyn. 2019 Jun;37(9):2242-2253.|[6]Park NY, et al. Triamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity. Arch Pharm Res. 2021 Jun;44(6):621-631.|[7]Daleau P, et al. Triamterene inhibits the delayed rectifier potassium current (IK) in guinea pig ventricular myocytes. Circ Res. 1994 Jun;74(6):1114-20.
CAS Number
– 396-01-0
Molecular Weight
– 253.26
Compound Purity
– 99.98
SMILES
– NC1=NC(N)=C2N=C(C3=CC=CC=C3)C(N)=NC2=N1
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease; Neurological Disease; Cardiovascular Disease
Solubility
– DMSO : 16.67 mg/mL (ultrasonic;adjust pH to 5 with HCl)|DMSO : 4.55 mg/mL (ultrasonic;adjust pH to 9 with NaOH)
Target
– G protein-coupled Bile Acid Receptor 1;Sodium Channel
Pathway
– GPCR/G Protein;Membrane Transporter/Ion Channel
Product type
– Reference compound
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