Download Files:
Trequinsin (hydrochloride)
$165 – $1,650
Products Details
Product Description
– Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of platelet CAMP phosphodiesterase (PDE), with an IC50 of 0.25 nM. Trequinsin hydrochloride (HL 725) is an extremely potent inhibitor of the aggregation of human platelets induced in vitro by ADP, collagen, thrombin and epinephrine[1][2][3].
Web ID
– HY-18740A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C24H28ClN3O3
References
– [1]D Ruppert,, et al. HL 725, an extremely potent inhibitor of platelet phosphodiesterase and induced platelet aggregation in vitro. Life Sci. 1982 Nov 8;31(19):2037-43.|[2]K C Agarwal, et al. Role of plasma adenosine in the antiplatelet action of HL 725, a potent inhibitor of cAMP phosphodiesterase: species differences. Thromb Res. 1987 Jul 15;47(2):191-200.|[3]Rachel C McBrinn, et al. Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. Br J Pharmacol. 2019 Dec;176(23):4521-4536.
CAS Number
– 78416-81-6
Molecular Weight
– 441.95
Compound Purity
– 99.96
SMILES
– O=C(N(CCC1=C2C=C(OC)C(OC)=C1)C2=C/3)N(C)C3=NC4=C(C)C=C(C)C=C4C.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– DMSO : 62.5 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– Phosphodiesterase (PDE)
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
