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Products Details
Product Description
– TPP-1, a peptide inhibitor, targets the interaction between programmed cell death protein 1 (PD-1) and its ligand (PD-L1), binding specifically to PD-L1 with a dissociation constant (Kd) of 94.67 nM. At a concentration of 20 µM, TPP-1 effectively counteracts the PD-L1-induced suppression of IFN-γ production in anti-CD3-stimulated isolated human CD4+ T cells. Furthermore, TPP-1 demonstrates significant efficacy in reducing tumor volume in a mouse xenograft model of HL-60 leukemia. This model involved HL-60 cells co-cultured with anti-CD3-activated isolated human CD4+ T cells, with TPP-1 administration at a dosage of 4 mg/kg showing notable antitumor activity.
Web ID
– T83724
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C107H150N34O32S2.HCl
Molecular Weight
– C107H150N34O32S2.HCl
SMILES
– O=C(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@@H](CC3=CNC=N3)C(N[C@@H](CS[H])C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](CS[H])C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N8CCC[C@H]8C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(NCC(NCC(N[C@@H](CO)C(N[C@@H](CCCCN[H])C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)[C@H](CO)N[H].Cl
Product type
– Peptide
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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