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Products Details
Product Description
– Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition, crucial in synthesizing various PROTACs, including BI-3663, a selective PTK2/FAK PROTAC. Using cereblon ligands, it targets E3 ligases to degrade PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
Web ID
– T17133
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H32O8S
References
– Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
CAS Number
– 217817-01-1
Molecular Weight
– C20H32O8S
SMILES
– S(OCCOCCOCCOCCC(OC(C)(C)C)=O)(=O)(=O)C1=CC=C(C)C=C1
Target
– Endogenous Metabolite
Pathway
– Others
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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