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Tocrifluor 1117
$936
Only 1000 item(s) left in stock.
Products Details
Product Description
– Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251 (HY-15443), is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm)[1][2].
Web ID
– HY-103336
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C56H53Cl2N7O5
References
– [1]Daly CJ, et al. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid-like’ receptors in small arteries. Br J Pharmacol. 2010 Feb;159(4):787-96.|[2]Singh NS, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016 Sep;111:757-766.
CAS Number
– 1186195-59-4
Molecular Weight
– 974.97
SMILES
– O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C4=CC=C(CCCNC(C5=CC6=C(C7(C8=C(OC9=C7C=CC(N(C)C)=C9)C=C(N(C)C)C=C8)OC6=O)C=C5)=O)C=C4)C=C3)=C1C)NN%10CCCCC%10
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Cannabinoid Receptor;GPR55
Isoform
– CB1
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
