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Tocilizumab
Price range: 357 CAD through 3,616 CAD
Products Details
Product Description
– Tocilizumab (Anti-Human IL6R) is a neutralizing antibody against human interleukin-6 receptor (IL-6R) that blocks the binding of IL-6 to IL-6R, thereby inhibiting both classical and trans signaling. It can be used to study rheumatoid arthritis and has been suggested as a possible drug for the treatment of severe COVID-19.
Web ID
– T9911
Storage Temperature
– -20℃
Shipping
– Blue Ice
Citations
– 1. Meng H, Fan L, Zhang C J, et al. Synthetic VSMCs Induce BBB Disruption Mediated by MYPT1 in Ischemic Stroke. iScience. 2021: 103047.
2. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765
3. Stauber T, Moschini G, Hussien A A, et al.IL-6 SIGNALING EXACERBATES HALLMARKS OF CHRONIC TENDON DISEASE BY STIMULATING PROGENITOR PROLIFERATION & MIGRATION TO DAMAGE.bioRxiv.2023: 2023.02. 13.528273.
4. Stauber T, Moschini G, Hussien A A, et al.Il-6 signaling exacerbates hallmarks of chronic tendon disease by stimulating reparative fibroblasts.eLife.2024, 12.
References
– Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70
CAS Number
– 375823-41-9
Molecular Weight
Compound Purity
– 0.995
Pathway
– Immunology/Inflammation
Product type
– Inhibitory Antibodies
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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