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TLK117

$180$280

Products Details

Product Description

– TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.

Web ID

– HY-13634B

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C23H27N3O6S

References

– [1]The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcomingcytostatic-drug resistance is also a strong inhibitor of glyoxalase I. Mol Pharmacol. 2000 Mar;57(3):619-24.|[2]McMillan DH, et al. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight. 2016 Jun 2;1(8). pii: e85717.

CAS Number

– 152684-53-2

Molecular Weight

– 473.54

Compound Purity

– 98.18

SMILES

– OC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(O)=O)=O)=O)=O

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology

Solubility

– DMSO : 150 mg/mL (ultrasonic)

Target

– Gutathione S-transferase

Pathway

– Metabolic Enzyme/Protease

Product type

– Peptides

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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