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TLK117
$180 – $280
Products Details
Product Description
– TLK117, the active metabolite of TLK199, selective inhibits Glutathione S-transferase P1–1 (GSTP1-1) with a Ki of 0.4 μM for GSTP. TLK117 also competitively inhibits glyoxalase I with a Ki of 0.56 μM.
Web ID
– HY-13634B
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C23H27N3O6S
References
– [1]The human glutathione transferase P1-1 specific inhibitor TER 117 designed for overcomingcytostatic-drug resistance is also a strong inhibitor of glyoxalase I. Mol Pharmacol. 2000 Mar;57(3):619-24.|[2]McMillan DH, et al. Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π. JCI Insight. 2016 Jun 2;1(8). pii: e85717.
CAS Number
– 152684-53-2
Molecular Weight
– 473.54
Compound Purity
– 98.18
SMILES
– OC([C@@H](N)CCC(N[C@@H](CSCC1=CC=CC=C1)C(N[C@H](C2=CC=CC=C2)C(O)=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– Gutathione S-transferase
Pathway
– Metabolic Enzyme/Protease
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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