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Product Description
– Tiprelestat is a potent human neutrophil elastase inhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1].
Web ID
– HY-106216
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C254H416N72O75S10
References
– [1]Wang J, et al. Elafin inhibits obesity, hyperglycemia, and liver steatosis in high-fat diet-treated male mice. Sci Rep. 2020 Jul 30;10(1):12785. |[2]Alejandre Alcazar MA, et al. Elafin Treatment Rescues EGFR-Klf4 Signaling and Lung Cell Survival in Ventilated Newborn Mice. Am J Respir Cell Mol Biol. 2018 Nov;59(5):623-634. |[3]Bellemare A, et al. Human pre-elafin inhibits a Pseudomonas aeruginosa-secreted peptidase and prevents its proliferation in complex media. Antimicrob Agents Chemother. 2008 Feb;52(2):483-90. |[4]Butler MW, et al. Elafin prevents lipopolysaccharide-induced AP-1 and NF-kappaB activation via an effect on the ubiquitin-proteasome pathway. J Biol Chem. 2006 Nov 17;281(46):34730-5.|[5]Nickel NP, et al. Elafin Reverses Pulmonary Hypertension via Caveolin-1-Dependent Bone Morphogenetic Protein Signaling. Am J Respir Crit Care Med. 2015 Jun 1;191(11):1273-86.
CAS Number
– 820211-82-3
Molecular Weight
– 5999.09
SMILES
– [Tiprelestat]
Clinical Information
– Phase 1
Research Area
– Infection; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Elastase
Pathway
– Metabolic Enzyme/Protease
Product type
– Peptides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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