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Thiodigalactoside
$45 – $215
Products Details
Product Description
– Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with Kd values of 24 μM, 49 μM for GAL1 and GAL3, respectively[1]. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats[2].
Web ID
– HY-130208
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C12H22O10S
References
– [1]Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56(3):1350-4.|[2]Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32.
CAS Number
– 51555-87-4
Molecular Weight
– 358.36
Compound Purity
– 99.0
SMILES
– O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@@H]1O)CO)S[C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@@H]2O)CO
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– H2O : 100 mg/mL (ultrasonic)
Target
– Galectin
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
