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Thapsigargin
Price range: 131 CAD through 912 CAD
Products Details
Product Description
– Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic reticulum.
Web ID
– TQ0302
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C34H50O12
Citations
– 1. Shang Z, Zhang S, Wang J, et al.TRIM25 predominately associates with anti-viral stress granules.Nature Communications.2024, 15(1): 4127.
2. Xu W, Wang Z, Liu T, et al.Eurycomanone inhibits osteosarcoma growth and metastasis by suppressing GRP78 expression.Journal of Ethnopharmacology.2024: 118709.
3. Wang L, Wu J, Sramek M, et al.Heterogeneous enhancer states orchestrate β cell responses to metabolic stress.Nature Communications.2024, 15(1): 9361.
4. Zhou J, Shi Y, Zhao L, et al.γ-Glutamylcysteine restores glucolipotoxicity-induced islet β-cell apoptosis and dysfunction via inhibiting endoplasmic reticulum stress.Toxicology and Applied Pharmacology.2025, 495: 117206.
References
– Wang H, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovial cells. ScientificWorldJournal. 2014 Feb 9;2014:605416.
CAS Number
– 67526-95-8
Molecular Weight
– C34H50O12
Compound Purity
– 0.993
SMILES
– CCCCCCCC(=O)O[C@@H]1[C@@H](OC(=O)C(C)=CC)C(C)=C2[C@@H]3OC(=O)[C@@](C)(O)[C@@]3(O)[C@H](C[C@](C)(OC(C)=O)[C@@H]12)OC(=O)CCC
Pathway
– Apoptosis|||Microbiology/Virology|||Membrane transporter/Ion channel|||Metabolism
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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