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Thalidomide-O-amido-C3-PEG3-C1-NH2
$550 – $1,250
Products Details
Product Description
– Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
Web ID
– HY-131646
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H35F3N4O11
References
– [1]Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016;26(21):5260-5262. doi:10.1016/j.bmcl.2016.09.048
CAS Number
– 1799711-29-7
Molecular Weight
– 648.58
Compound Purity
– 99.48
SMILES
– O=C(NCCCOCCOCCOCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.O=C(O)C(F)(F)F
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 200 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
