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Thalidomide-NH-PEG2-C2-NH-Boc
$200 – $300
Products Details
Product Description
– Thalidomide-NH-PEG2-C2-NH-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a PEG linker used for dBRD9 (compound 6) synthesis. dBRD9 is a selective BRD9 probe PROTAC degrader for the study of BAF complex biology[1].
Web ID
– HY-130853
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H32N4O8
References
– [1]David Remillard, et al. Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.2017 May 15;56(21):5738-5743.
CAS Number
– 2097509-40-3
Molecular Weight
– 504.53
Compound Purity
– 98.37
SMILES
– O=C(OC(C)(C)C)NCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– Cereblon
Pathway
– PROTAC
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
