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Products Details
Product Description
– Thalidomide-NH-C10-COOH (compound 6b) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based von Hippel-Lindau (VHL) ligand and a linker used in PROTAC technology[1].
Web ID
– HY-130716
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H31N3O6
References
– [1]Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera. Sci Rep. 2019 Dec 23;9(1):19654.
CAS Number
– 2428400-33-1
Molecular Weight
– 457.52
SMILES
– O=C(N(C1=O)C(C(N2)=O)CCC2=O)C3=C1C=CC=C3NCCCCCCCCCCC(O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– E3 Ligase Ligand-Linker Conjugates
Isoform
– von Hippel-Lindau (VHL)
Pathway
– PROTAC
Product type
– Reference compound
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