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TH287 hydrochloride
Price range: 74 CAD through 600 CAD
Products Details
Product Description
– TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
Web ID
– T2069L
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C11H11Cl3N4
References
– Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.
CAS Number
– 1638211-05-8
Molecular Weight
– C11H11Cl3N4
Compound Purity
– 0.995
SMILES
– NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC)=N1.[H]Cl
Target
– Src
Pathway
– Cell Cycle/Checkpoint|||DNA Damage/DNA Repair
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
