Tezacaftor
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Tezacaftor

SKU T2263-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 54 CAD through 850 CAD

Products Details

Product Description

– Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.

Web ID

– T2263

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C26H27F3N2O6

Citations

– 1. Jarosz-Griffiths H H, Scambler T, Wong C H, et al. Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis. ELife. 2020, 9: e54556 2. Sondo E, Cresta F, Pastorino C, et al. The L467F-F508del Complex Allele Hampers Pharmacological Rescue of Mutant CFTR by Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Patients: The Value of the Ex Vivo Nasal Epithelial Model to Address Non-Responders to CFTR-Modulating Drugs. International Journal of Molecular Sciences. 2022, 23(6): 3175. 3. Baldassarri M, Zguro K, Tomati V, et al.Gain-and Loss-of-Function CFTR Alleles Are Associated with COVID-19 Clinical Outcomes.Cells.2022, 11(24): 4096. 4. Tomati V, Costa S, Capurro V, et al.Rescue by elexacaftor-tezacaftor-ivacaftor of the G1244E cystic fibrosis mutation’s stability and gating defects are dependent on cell background.Journal of Cystic Fibrosis.2022

References

– Vertex to host investor conference

CAS Number

– 1152311-62-0

Molecular Weight

– C26H27F3N2O6

Compound Purity

– 0.9994

SMILES

– CC(C)(CO)c1cc2cc(NC(=O)C3(CC3)c3ccc4OC(F)(F)Oc4c3)c(F)cc2n1C[C@@H](O)CO

Pathway

– Membrane transporter/Ion channel|||Autophagy

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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