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Terbinafine hydrochloride
$66 – $117
Products Details
Product Description
– Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria[1][2][3]. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Web ID
– HY-17395
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H26ClN
Citations
– Cell Death Dis. 2021 May 13;12(5):482.|Adv Healthc Mater. 2023 May 20;e2300018.|Cancer Commun (Lond). 2021 Jul 16.|Infect Drug Resist. 2022: 7459-7473.|Research Square Preprint. 2023 Sep 26.
References
– [1]Ciftci E, et al. Mupirocin vs terbinafine in impetigo.Indian J Pediatr. 2002 Aug;69(8):679-82.|[2]Ryder NS, et al. Terbinafine: mode of action and properties of the squalene epoxidase inhibition. Br J Dermatol. 1992 Feb;126 Suppl 39:2-8.|[3]Mieth H, et al. Preclinical evaluation of terbinafine in vivo. Clin Exp Dermatol. 1989 Mar;14(2):104-8.
CAS Number
– 78628-80-5
Molecular Weight
– 327.89
Compound Purity
– 99.78
SMILES
– CN(C/C([H])=C([H])/C#CC(C)(C)C)CC1=CC=CC2=CC=CC=C21.[H]Cl
Clinical Information
– Launched
Research Area
– Infection
Solubility
– DMSO : 60 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Antibiotic;Bacterial;Fungal
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
