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Tepotinib
Price range: 53 CAD through 1,294 CAD
Products Details
Product Description
– Tepotinib (EMD-1214063) is a c-MET tyrosine kinase inhibitor (IC50=3 nM) that is selective, orally active, and ATP-competitive. Tepotinib has antitumor effect and is used in the treatment of non-small cell lung cancer.
Web ID
– T6121
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C29H28N6O2
Citations
– 1. Li P, Jia C, Fan Z, et al.Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations.Acta Pharmaceutica Sinica B.2023
2. Thu Y M, Suzawa K, Tomida S, et al.PAI-1 mediates acquired resistance to MET-targeted therapy in non-small cell lung cancer.PloS one.2024, 19(5): e0300644.
3. Ying S, Chi H, Wu X, et al.Selective and Orally Bioavailable c-Met PROTACs for the Treatment of c-Met-Addicted Cancer.Journal of Medicinal Chemistry.2024
References
– Bladt F, et al. Clin Cancer Res, 2013, 19(11), 2941-2951.
CAS Number
– 1100598-32-0
Molecular Weight
– C29H28N6O2
Compound Purity
– 0.9991
SMILES
– CN1CCC(COc2cnc(nc2)-c2cccc(Cn3nc(ccc3=O)-c3cccc(c3)C#N)c2)CC1
Pathway
– Tyrosine Kinase/Adaptors
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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