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Tenofovir Disoproxil
$32 – $280
Products Details
Product Description
– Tenofovir Disoproxil (Bis(POC)-PMPA) is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
Web ID
– HY-13782A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C19H30N5O10P
Citations
– Department od Analytical Chemistry, Charles University. 2019 Jun.|Int J Antimicrob Agents. 2019 Dec;54(6):814-819.|J Gastroenterol. 2021 Feb;56(2):168-180.|J Neuroimmune Pharmacol. 2017 Dec;12(4):682-692.|J Neuroimmune Pharmacol. 2019 Jul 23;10.1007/s11481-019-09862-1.|Sci Rep. 2019 Nov 20;9(1):17158.Â
References
– [1]Musumeci G, et al. M48U1 and Tenofovir combination synergistically inhibits HIV infection in activated PBMCs and human cervicovaginal histocultures. Sci Rep. 2017 Feb 1;7:41018|[2]Wahl A, et al. Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model. Sci Rep. 2017 Feb 1;7:41098|[3]Menne S, Cote PJ, Korba BE, Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother. 2005 Jul;49(7):2720-8.|[4]Murphy RA, et al. Establishment of HK-2 Cells as a Relevant Model to Study Tenofovir-Induced Cytotoxicity. Int J Mol Sci. 2017 Mar 1;18(3)
CAS Number
– 201341-05-1
Molecular Weight
– 519.44
Compound Purity
– 99.84
SMILES
– O=C(OC(C)C)OCOP(OCOC(OC(C)C)=O)(CO[C@H](C)CN1C=NC2=C(N)N=CN=C12)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : ≥ 38 mg/mL
Target
– HBV;HIV;Reverse Transcriptase
Isoform
– HIV-1
Pathway
– Anti-infection
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
