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TCO-SS-amine
SKU
HY-136039-10 mg
Category ADC Related
Tags ADC Linker, Antibody-drug Conjugate/ADC Related, Cancer
$380 – $600
Products Details
Product Description
– TCO-SS-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-SS-amine is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Web ID
– HY-136039
Storage Temperature
– -20°C (Powder, protect from light)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C13H24N2O2S2
References
– [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
Molecular Weight
– 304.47
Compound Purity
– 95.0
SMILES
– O=C(NCCSSCCN)O[C@@H]1CC/C=C([H])/CCC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Linker
Isoform
– Cleavable Linker;Disulfide Cleavable Linker
Pathway
– Antibody-drug Conjugate/ADC Related
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.